RSV vs. Flu vs. COVID-19: Understanding the Differences

COVID-19; vaccine; Infection Prevention/Control; GetVaccinated
 

​As we head into the fall and winter, long term care providers are preparing for an increased spread and incidence of respiratory viruses, namely RSV, flu, and COVID-19. All three respiratory viruses can be particularly dangerous for residents with weakened immune systems and other underlying health conditions. While the three viruses share many similarities, there are also key differences in treatment options and symptoms. Read on to understand more about the differences and similarities between these viruses.

 

RSV 

COVID 

Flu 

Vaccination Available 

Yes- One time 

Yes- Annual 

Yes- Annual 

Ideal Vaccination Window1 

September-October 

 

 

September-October 

September-October  

Vaccination Information Statement  

How it spreads23 

Virus droplets from a cough or sneeze in your eyes, nose, or mouth 

Contact with a contaminated surface 

Virus droplets from a cough or sneeze in your eyes, nose, or mouth 

 

Contact with a contaminated surface 

Virus droplets from a cough or sneeze in your eyes, nose, or mouth 

 

Contact with a contaminated surface 

How long do symptoms appear after exposure or infection45 

4 to 6 days  

2 to 5 days, but up to 14 days 

1 to 4 days 

Contagious Period67 

3 to 8 days 

 

People with weakened immune systems can be contagious for as long as 4 weeks 

1–2 days before and up to 8–10 days after symptoms begin 

1 day before and up to 57 days after symptoms begin 

 

People with weakened immune systems may be contagious for longer periods of time 

Common Symptoms8 

  • Runny nose 
  • Decrease in appetite 
  • Coughing 
  • Sneezing 
  • Fever 
  • Wheezing 
  • Fever or chills 
  • Cough 
  • Shortness of breath or difficulty breathing 
  • Sore throat 
  • Congestion or runny nose 
  • New loss of taste or smell 
  • Fatigue 
  • Muscle or body aches 
  • Headache 
  • Nausea or vomiting 
  • Diarrhea 

 

  • Fever or chills 
  • cough 
  • sore throat 
  • runny or stuffy nose 
  • muscle or body aches 
  • headaches 
  • fatigue  

 

Testing Options 

Molecular and Antigen 

Molecular and Antigen 

Molecular and Antigen 

Infection Control Practices 

Treatment Options 

Antiviral treatments are not recommended 

  • Antivirals are recommended for individuals at high risk for severe COVID-19, including hospitalization and death. 
  • Several antiviral treatments are available. 
  • Treatments must be initiated between 5 or 7 days of symptom onset.  

 

  • Antiviral treatment is recommended as soon as possible for any patient with suspected or confirmed influenza who is hospitalized; has severe, complicated, or progressive illness; or is at higher risk for influenza complications. 
  • Several antiviral treatments are available.  


Below are resources to check out for more explanation on the differences between these three viruses, as well as how to handle co-circulation: 

  • National Foundation for Infectious Diseases: Check out this table from NFID highlighting common symptoms of each virus. 
  • CDC Testing and Management Considerations for Nursing Home Residents with Acute Respiratory Illness Symptoms when SARS-CoV-2 and Influenza Viruses are Co-circulating: When COVID-19 and Flu are co-circulating in the nursing home, providers should use this infection control guidance from the CDC.   

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